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Autonomic Regulation Therapy in Heart Failure.


ABSTRACT: Autonomic regulation therapy (ART) is a rapidly emerging therapy in the management of congestive heart failure secondary to systolic dysfunction. Modulation of the cardiac neuronal hierarchy can be achieved with bioelectronics modulation of the spinal cord, cervical vagus, baroreceptor, or renal nerve ablation. This review will discuss relevant preclinical and clinical research in ART for systolic heart failure. Understanding mechanistically what is being stimulated within the autonomic nervous system by such device-based therapy and how the system reacts to such stimuli is essential for optimizing stimulation parameters and for the future development of effective ART.

SUBMITTER: Buckley U 

PROVIDER: S-EPMC4607027 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Autonomic Regulation Therapy in Heart Failure.

Buckley Una U   Shivkumar Kalyanam K   Ardell Jeffrey L JL  

Current heart failure reports 20150801 4


Autonomic regulation therapy (ART) is a rapidly emerging therapy in the management of congestive heart failure secondary to systolic dysfunction. Modulation of the cardiac neuronal hierarchy can be achieved with bioelectronics modulation of the spinal cord, cervical vagus, baroreceptor, or renal nerve ablation. This review will discuss relevant preclinical and clinical research in ART for systolic heart failure. Understanding mechanistically what is being stimulated within the autonomic nervous  ...[more]

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