SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution.
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ABSTRACT:
SUBMITTER: Plyler ZE
PROVIDER: S-EPMC4607513 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution.
Plyler Zackery E ZE Hill Aubrey E AE McAtee Christopher W CW Cui Xiangqin X Moseley Leah A LA Sorscher Eric J EJ
Genome biology and evolution 20150806 9
In this study, we show novel DNA motifs that promote single nucleotide polymorphism (SNP) formation and are conserved among exons, introns, and intergenic DNA from mice (Sanger Mouse Genomes Project), human genes (1000 Genomes), and tumor-specific somatic mutations (data from TCGA). We further characterize SNPs likely to be very recent in origin (i.e., formed in otherwise congenic mice) and show enrichment for both synonymous and parallel DNA variants occurring under circumstances not attributab ...[more]
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