Dataset Information

Interictal, circulating sphingolipids in women with episodic migraine: A case-control study.

ABSTRACT:

Objective

To evaluate interictal, circulating sphingolipids in women migraineurs.

Methods

In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled with tandem mass spectrometry using multiple reaction monitoring. Multivariate logistic regression was used to examine the association between serum sphingolipids and EM odds. A recursive partitioning decision tree based on the serum concentrations of 10 sphingolipids was used to determine the presence or absence of EM in a subset of participants.

Results

Total ceramide (EM 6,502.9 ng/mL vs controls 10,518.5 ng/mL; p<0.0001) and dihydroceramide (EM 39.3 ng/mL vs controls 63.1 ng/mL; p<0.0001) levels were decreased in those with EM as compared with controls. Using multivariate logistic regression, each SD increase in total ceramide (odds ratio [OR] 0.07; 95% confidence interval [CI]: 0.02, 0.22; p<0.001) and total dihydroceramide (OR 0.05; 95% CI: 0.01, 0.21; p<0.001) levels was associated with more than 92% reduced odds of migraine. Although crude sphingomyelin levels were not different in EM compared with controls, after adjustments, every SD increase in the sphingomyelin species C18:0 (OR 4.28; 95% CI: 1.87, 9.81; p=0.001) and C18:1 (OR 2.93; 95% CI: 1.55, 5.54; p=0.001) was associated with an increased odds of migraine. Recursive portioning models correctly classified 14 of 14 randomly selected participants as EM or control.

Conclusion

These results suggest that sphingolipid metabolism is altered in women with EM and that serum sphingolipid panels may have potential to differentiate EM presence or absence.

Classification of evidence

This study provides Class III evidence that serum sphingolipid panels accurately distinguish women with migraine from women without migraine.

SUBMITTER: Peterlin BL

PROVIDER: S-EPMC4607595 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Publications

Interictal, circulating sphingolipids in women with episodic migraine: A case-control study.

Peterlin B Lee BL Mielke Michelle M MM Dickens Alex M AM Chatterjee Subroto S Dash Paul P Alexander Guillermo G Vieira Rebeca V A RV Bandaru Veera Venkata Ratnam VV Dorskind Joelle M JM Tietjen Gretchen E GE Haughey Norman H NH

Neurology 20150909 14

<h4>Objective</h4>To evaluate interictal, circulating sphingolipids in women migraineurs.<h4>Methods</h4>In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled with tandem mass spectrometry using multiple reaction monitoring. Multivariate logistic regression was used to examine the association between serum sphingolipids and E ...[more]

PMID: 26354990

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Dataset Information

Interictal, circulating sphingolipids in women with episodic migraine: A case-control study.

Objective

Methods

Results

Conclusion

Classification of evidence

Publications

Interictal, circulating sphingolipids in women with episodic migraine: A case-control study.

Similar Datasets

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