Ontology highlight
ABSTRACT:
SUBMITTER: Singh MK
PROVIDER: S-EPMC4607626 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20150623 21
Both the Wnt/β-catenin signaling pathway and small GTPases of the ADP-ribosylation factors (ARF) family play important roles in regulating cell development, homeostasis and fate. The previous report of QS11, a small molecule Wnt synergist that binds to ARF GTPase-activating protein 1 (ARFGAP1), suggests a role for ARFGAP1 in the Wnt/β-catenin pathway. However, direct inhibition of enzymatic activity of ARFGAP1 by QS11 has not been established. Whether ARFGAP1 is the only target that contributes ...[more]