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Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis.


ABSTRACT: Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -190C?>?A (rs2301365) polymorphism was identified as a risk factor for male infertility under all models. Interestingly, rs1646022 and rs737008 polymorphisms exerted protective effects against male sterility in Asian and population-based under some models. No associations between the remaining SNPs and male sterility were observed.

SUBMITTER: Jiang W 

PROVIDER: S-EPMC4607923 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis.

Jiang Weijun W   Sun Hui H   Zhang Jing J   Zhou Qing Q   Wu Qiuyue Q   Li Tianfu T   Zhang Cui C   Li Weiwei W   Zhang Mingchao M   Xia Xinyi X  

Scientific reports 20151016


Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -1  ...[more]

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