Unknown

Dataset Information

0

The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus.


ABSTRACT: Current evidence shows that the CD40-CD40 ligand (CD40-CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investigate whether a CD40 gene single nucleotide polymorphism (SNP) is associated with SLE and CD40 expression in the Chinese population. We included controls (n?=?220) and patients with either SLE (n =205) in the study.The gene polymorphism was measured using Snapshot SNP genotyping assays and confirmed by sequencing. We analyzed three single nucleotide polymorphisms of CD40 gene rs1883832C/T, rs1569723A/C and rs4810485G/T in 205 patients with SLE and 220 age-and sex-matched controls. Soluble CD40 (sCD40) levels were measured by ELISA.There were significant differences in the genotype and allele frequencies of CD40 gene rs1883832C/T polymorphism between the group of patients with SLE and the control group (P?

SUBMITTER: Chen JM 

PROVIDER: S-EPMC4608213 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus.

Chen Jian-Ming JM   Guo Jing J   Wei Chuan-Dong CD   Wang Chun-Fang CF   Luo Hong-Cheng HC   Wei Ye-Sheng YS   Lan Yan Y  

BMC genetics 20151016


<h4>Background</h4>Current evidence shows that the CD40-CD40 ligand (CD40-CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investigate whether a CD40 gene single nucleotide polymorphism (SNP) is associated with SLE and CD40 expression in the Chinese population. We included controls (n = 220) and patients with either SLE (n =205) in the study.<h4>Methods</h4>The gene polymorphism was measured using S  ...[more]

Similar Datasets

| S-EPMC7794606 | biostudies-literature
| S-EPMC6900383 | biostudies-literature
| S-EPMC7521335 | biostudies-literature
| S-EPMC7490265 | biostudies-literature
| S-EPMC5420091 | biostudies-literature
| S-EPMC5680319 | biostudies-literature
| S-EPMC6668546 | biostudies-literature
| S-EPMC4655060 | biostudies-literature
| S-EPMC7803765 | biostudies-literature
| S-EPMC3653634 | biostudies-literature