Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.
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ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC4608387 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
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Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.
Yang Jiyuan J Jacobsen Michael T MT Pan Huaizhong H Kopecek Jindrich J
Macromolecular bioscience 20100401 4
Biodegradable hydrogels were synthesized by the click reaction of 4-arm azido-terminated PEG differing in molecular weight (2,100 and 8,800) and two alkyne-terminated peptides: [alkyne]-GFLGK-[alkyne] and ([alkyne]-GFLG)(2)K. The physical properties of in situ formed hydrogels were examined. The hydrogels were highly elastic as determined by rheological and microrheological studies. Swelling degree and enzymatic degradation by papain were dependent on the molecular weight of the PEG, but not the ...[more]
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