Waterborne Risperidone Decreases Stress Response in Zebrafish.
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ABSTRACT:
SUBMITTER: Idalencio R
PROVIDER: S-EPMC4608780 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Waterborne Risperidone Decreases Stress Response in Zebrafish.
Idalencio Renan R Kalichak Fabiana F Rosa João Gabriel Santos JG de Oliveira Tiago Acosta TA Koakoski Gessi G Gusso Darlan D Abreu Murilo Sander de MS Giacomini Ana Cristina Varrone AC Barcellos Heloísa Helena de Alcântara HH Piato Angelo L AL Barcellos Leonardo José Gil LJ
PloS one 20151016 10
The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. Th ...[more]
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