Ontology highlight
ABSTRACT:
SUBMITTER: Bosnyak E
PROVIDER: S-EPMC4608955 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Bosnyák Edit E Kamson David O DO Behen Michael E ME Barger Geoffrey R GR Mittal Sandeep S Juhász Csaba C
EJNMMI research 20151017 1
<h4>Background</h4>Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor patients indicated abnormal tryptophan metabolism not only in the tumor mass but also in normal-appearing contralateral brain. In the present study, we explored if tryptoph ...[more]