Dataset Information

Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial.

ABSTRACT:

Background

This article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in Parkinson's disease (PD) randomized, controlled trial.

Methods

This study was a prospective, parallel-group, single-center trial. Fifty-one nondemented patients with mild-to-moderate PD were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resistance Exercise Training (PRET) and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention (BTA).

Results

Eighteen patients in mFC and 20 patients in PRET completed the trial. At 12 and at 24 months, no differences between groups were observed. At 12 months, relative to baseline, mFC improved on the Digit Span (estimated change: 0.3; interquartile range: 0, 0.7; P = 0.04) and Stroop (0.3; 0, 0.6; P = 0.04), and PRET improved only on the Digit Span (0.7; 0.3, 1; P < 0.01). At 24 months, relative to baseline, mFC improved on the Digit Span (0.7; 0.3, 1.7; P < 0.01) and Stroop (0.3; 0.1, 0.5; P = 0.03), whereas PRET improved on the Digit Span (0.5; 0.2, 0.8; P < 0.01), Stroop (0.2; -0.1, 0.6; P = 0.048), and BTA (0.3; 0, 0.8; P = 0.048). No neurological or cognitive adverse events were observed.

Conclusions

This study provides class IV level of evidence that 24 months of PRET or mFC may improve attention and working memory in nondemented patients with mild-to-moderate Parkinson's disease.

SUBMITTER: David FJ

PROVIDER: S-EPMC4609235 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Publications

Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial.

David Fabian J FJ Robichaud Julie A JA Leurgans Sue E SE Poon Cynthia C Kohrt Wendy M WM Goldman Jennifer G JG Comella Cynthia L CL Vaillancourt David E DE Corcos Daniel M DM

Movement disorders : official journal of the Movement Disorder Society 20150706 12

<h4>Background</h4>This article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in Parkinson's disease (PD) randomized, controlled trial.<h4>Methods</h4>This study was a prospective, parallel-group, single-center trial. Fifty-one nondemented patients with mild-to-moderate PD were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resis ...[more]

PMID: 26148003

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Dataset Information

Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial.

Background

Methods

Results

Conclusions

Publications

Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial.

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