Ontology highlight
ABSTRACT:
SUBMITTER: Morris ZS
PROVIDER: S-EPMC4609259 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Morris Zachary S ZS Weichert Jamey P JP Saker Jarob J Armstrong Eric A EA Besemer Abigail A Bednarz Bryan B Kimple Randall J RJ Harari Paul M PM
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20150626 3
<h4>Background and purpose</h4>CLR1404 is a phospholipid ether that exhibits selective uptake and retention in malignant tissues. Radiolabeled CLR1404 enables tumor-specific positron-emission tomography (PET) imaging ((124)I) and targeted delivery of ionizing radiation ((131)I). Here we describe the first preclinical studies of this diapeutic molecule in head and neck cancer (HNC) models.<h4>Material and methods</h4>Tumor-selective distribution of (124)I-CLR1404 and therapeutic efficacy of (131) ...[more]