Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC4609298 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20151008 2
Epidermal growth factor receptor (EGFR) gene amplification and mutations are the most common oncogenic events in glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, genotyped clinical samples, and TCGA data, we show that EGFR mutations remodel the activated enhancer landscape of GBM, promoting tumorigenesis through a SOX9 and FOXG1-dependent transcriptional regul ...[more]