Ontology highlight
ABSTRACT:
SUBMITTER: Vaisman BL
PROVIDER: S-EPMC4609362 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Vaisman Boris L BL Vishnyakova Tatyana G TG Freeman Lita A LA Amar Marcelo J MJ Demosky Stephen J SJ Liu Chengyu C Stonik John A JA Sampson Maureen L ML Pryor Milton M Bocharov Alexander V AV Eggerman Thomas L TL Patterson Amy P AP Remaley Alan T AT
BioMed research international 20151004
The role of scavenger receptor class B, type I (SR-BI) in endothelial cells (EC) was examined in several novel transgenic mouse models expressing SR-BI in endothelium of mice with normal C57Bl6/N, apoE-KO, or Scarb1-KO backgrounds. Mice were also created expressing SR-BI exclusively in endothelium and liver. Endothelial expression of the Tie2-Scarb1 transgene had no significant effect on plasma lipoprotein levels in mice on a normal chow diet but on an atherogenic diet, significantly decreased p ...[more]