Ontology highlight
ABSTRACT:
SUBMITTER: Wunsch E
PROVIDER: S-EPMC4609469 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Wunsch Ewa E Klak Marta M Wasik Urszula U Milkiewicz Malgorzata M Blatkiewicz Malgorzata M Urasinska Elzbieta E Barbier Olivier O Bielicki Dariusz D Bogdanos Dimitrios P DP Elias Elwyn E Milkiewicz Piotr P
Journal of immunology research 20151004
<h4>Background/aim</h4>Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis in chronic cholestatic conditions: primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC).<h4>Materials/methods</h4>Western-blot/PCRs for SULT2A1/PXR were performed in PSC (n = 11), PBC (n = 19), and control liver tissues (n = 19). PXR and SULT2A1 mRNA wa ...[more]