Ontology highlight
ABSTRACT:
SUBMITTER: Clark-Matott J
PROVIDER: S-EPMC4609600 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Clark-Matott Joanne J Saleem Ayesha A Dai Ying Y Shurubor Yevgeniya Y Ma Xiaoxing X Safdar Adeel A Beal Myron Flint MF Tarnopolsky Mark M Simon David K DK
Neurobiology of aging 20150721 11
Mitochondrial DNA (mtDNA) mutator mice express a mutated form of mtDNA polymerase gamma that results an accelerated accumulation of somatic mtDNA mutations in association with a premature aging phenotype. An exploratory metabolomic analysis of cortical metabolites in sedentary and exercised mtDNA mutator mice and wild-type littermate controls at 9-10 months of age was performed. Pathway analysis revealed deficits in the neurotransmitters acetylcholine, glutamate, and aspartate that were ameliora ...[more]