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Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus.


ABSTRACT: We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ?1:3,200 in an admission sample or of a ?4-fold rise to ?1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).

SUBMITTER: Lim C 

PROVIDER: S-EPMC4609688 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus.

Lim Cherry C   Blacksell Stuart D SD   Laongnualpanich Achara A   Kantipong Pacharee P   Day Nicholas P J NP   Paris Daniel H DH   Limmathurotsakul Direk D  

Journal of clinical microbiology 20150909 11


We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%). ...[more]

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