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Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.

ABSTRACT: Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention.

SUBMITTER: Whitfield MG

PROVIDER: S-EPMC4609709 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.

Whitfield Michael G MG Warren Robin M RM Streicher Elizabeth M EM Sampson Samantha L SL Sirgel Frik A FA van Helden Paul D PD Mercante Alexandra A Willby Melisa M Hughes Kelsey K Birkness Kris K Morlock Glenn G van Rie Annelies A Posey James E JE

Journal of clinical microbiology 20150819 11

Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention. ...[more]

PMID: 26292310

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A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

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Structure guided prediction of Pyrazinamide resistance mutations in pncA.

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Project description: Not available

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