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Targeting breast cancer with sugar-coated carbon nanotubes.

ABSTRACT: To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting.Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells in vitro and in vivo.Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation in vivo. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.

SUBMITTER: Fahrenholtz CD

PROVIDER: S-EPMC4610120 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Targeting breast cancer with sugar-coated carbon nanotubes.

Fahrenholtz Cale D CD Hadimani Mallinath M King S Bruce SB Torti Suzy V SV Singh Ravi R

Nanomedicine (London, England) 20150821 16

<h4>Aims</h4>To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting.<h4>Materials & methods</h4>Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells in vitro and in vivo.<h4>Results & conclusion</h4>Binding of glyco-MWCNTs in breast cancer cells is mediated by specifi ...[more]

PMID: 26296098

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