Unknown

Dataset Information

0

Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection.


ABSTRACT: Dysregulation of microRNA-21 (miR-21) is independently associated with HIV infection, pulmonary arterial hypertension (PAH), and hepatitis C virus (HCV) infection. To assess the expression of miR-21 in these overlapping comorbidities, we measured plasma miR-21 in HIV with and without PAH and then stratified by concomitant HCV infection. MiR-21 was increased in HIV and HIV-PAH versus uninfected subjects, but it did not differ between these groups. HIV/HCV coinfection correlated with even higher miR-21 levels within the HIV-infected population. These data reveal specific regulation of plasma miR-21 in HIV, HIV/HCV coinfection, and PAH and suggest that miR-21 may integrate complex disease-specific signaling in the setting of HIV infection.

SUBMITTER: Parikh VN 

PROVIDER: S-EPMC4610144 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection.

Parikh Victoria N VN   Park Joseph J   Nikolic Ivana I   Channick Richard R   Yu Paul B PB   De Marco Teresa T   Hsue Priscilla Y PY   Chan Stephen Y SY  

Journal of acquired immune deficiency syndromes (1999) 20151101 3


Dysregulation of microRNA-21 (miR-21) is independently associated with HIV infection, pulmonary arterial hypertension (PAH), and hepatitis C virus (HCV) infection. To assess the expression of miR-21 in these overlapping comorbidities, we measured plasma miR-21 in HIV with and without PAH and then stratified by concomitant HCV infection. MiR-21 was increased in HIV and HIV-PAH versus uninfected subjects, but it did not differ between these groups. HIV/HCV coinfection correlated with even higher m  ...[more]

Similar Datasets

| S-EPMC8551560 | biostudies-literature
| S-EPMC2359164 | biostudies-other
| S-EPMC3511890 | biostudies-literature
| S-EPMC5661989 | biostudies-literature
| S-EPMC9333554 | biostudies-literature
| S-EPMC4214386 | biostudies-other
| S-EPMC7060367 | biostudies-literature
| S-EPMC6817383 | biostudies-literature
| S-EPMC3210030 | biostudies-literature
| S-EPMC4576938 | biostudies-literature