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B(12)-mediated, long wavelength photopolymerization of hydrogels.

ABSTRACT: Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600-900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. Photoactivation occurs within a range of skin type models containing high biochromophore concentrations.

SUBMITTER: Rodgers ZL

PROVIDER: S-EPMC4610811 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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B(12)-mediated, long wavelength photopolymerization of hydrogels.

Rodgers Zachary L ZL Hughes Robert M RM Doherty Laura M LM Shell Jennifer R JR Molesky Brian P BP Brugh Alexander M AM Forbes Malcolm D E MD Moran Andrew M AM Lawrence David S DS

Journal of the American Chemical Society 20150227 9

Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they ...[more]

PMID: 25697508

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