Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Y
PROVIDER: S-EPMC4610872 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Xiao Yun Y Qiao Guilin G Tang Juan J Tang Rong R Guo Hui H Warwar Samantha S Langdon Wallace Y WY Tao Lijian L Zhang Jian J
Journal of immunology (Baltimore, Md. : 1950) 20150928 9
Previously, we demonstrated that CD28 and CTLA-4 signaling control Casitas-B-lineage lymphoma (Cbl)-b protein expression, which is critical for T cell activation and tolerance induction. However, the molecular mechanism(s) of this regulation remains to be elucidated. In this study, we found that Cbl-b fails to undergo tyrosine phosphorylation upon CD3 stimulation because SHP-1 is recruited to and dephosphorylates Cbl-b, whereas CD28 costimulation abrogates this interaction. In support of this fi ...[more]