Ontology highlight
ABSTRACT:
SUBMITTER: Gualerzi CO
PROVIDER: S-EPMC4611024 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Gualerzi Claudio O CO Pon Cynthia L CL
Cellular and molecular life sciences : CMLS 20150811 22
Initiation of mRNA translation is a major checkpoint for regulating level and fidelity of protein synthesis. Being rate limiting in protein synthesis, translation initiation also represents the target of many post-transcriptional mechanisms regulating gene expression. The process begins with the formation of an unstable 30S pre-initiation complex (30S pre-IC) containing initiation factors (IFs) IF1, IF2 and IF3, the translation initiation region of an mRNA and initiator fMet-tRNA whose codon and ...[more]