Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC4611618 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sun Xiaoyu X Driscoll Meghan K MK Guven Can C Das Satarupa S Parent Carole A CA Fourkas John T JT Losert Wolfgang W
Proceedings of the National Academy of Sciences of the United States of America 20150928 41
Many biological and physiological processes depend upon directed migration of cells, which is typically mediated by chemical or physical gradients or by signal relay. Here we show that cells can be guided in a single preferred direction based solely on local asymmetries in nano/microtopography on subcellular scales. These asymmetries can be repeated, and thereby provide directional guidance, over arbitrarily large areas. The direction and strength of the guidance is sensitive to the details of t ...[more]