Ontology highlight
ABSTRACT:
SUBMITTER: Rotgers E
PROVIDER: S-EPMC4611710 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rotgers E E Rivero-Müller A A Nurmio M M Parvinen M M Guillou F F Huhtaniemi I I Kotaja N N Bourguiba-Hachemi S S Toppari J J
Cell death & disease 20140605
The retinoblastoma protein (RB) is essential for normal cell cycle control. RB function depends, at least in part, on interactions with the E2F family of DNA-binding transcription factors (E2Fs). To study the role of RB in the adult testis, a Sertoli cell (SC)-specific Rb knockout mouse line (SC-RbKO) was generated using the Cre/loxP recombination system. SC-RbKO mice exhibited an age-dependent testicular atrophy, impaired fertility, severe SC dysfunction, and spermatogenic defects. Removal of R ...[more]