Ontology highlight
ABSTRACT:
SUBMITTER: Kim HJ
PROVIDER: S-EPMC4611728 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kim H-J HJ Oh G-S GS Shen A A Lee S-B SB Choe S-K SK Kwon K-B KB Lee S S Seo K-S KS Kwak T H TH Park R R So H-S HS
Cell death & disease 20140612
Cisplatin (cis-diaminedichloroplatinum-II) is an extensively used chemotherapeutic agent, and one of its most adverse effects is ototoxicity. A number of studies have demonstrated that these effects are related to oxidative stress and DNA damage. However, the precise mechanism underlying cisplatin-associated ototoxicity is still unclear. The cofactor nicotinamide adenine dinucleotide (NAD(+)) has emerged as a key regulator of cellular energy metabolism and homeostasis. Here, we demonstrate for t ...[more]