Ontology highlight
ABSTRACT:
SUBMITTER: Wagner J
PROVIDER: S-EPMC4612332 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Acta neuropathologica 20151006 5
Pathological tau aggregation leads to filamentous tau inclusions and characterizes neurodegenerative tauopathies such as Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. Tau aggregation coincides with clinical symptoms and is thought to mediate neurodegeneration. Transgenic mice overexpressing mutant human P301S tau exhibit many neuropathological features of human tauopathies including behavioral deficits and increased mortality. Here, we show that the di ...[more]