Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
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ABSTRACT:
SUBMITTER: Teo AE
PROVIDER: S-EPMC4612399 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
Teo Ada E D AE Garg Sumedha S Shaikh Lalarukh Haris LH Zhou Junhua J Karet Frankl Fiona E FE Gurnell Mark M Happerfield Lisa L Marker Alison A Bienz Mariann M Azizan Elena A B EA Brown Morris J MJ
The New England journal of medicine 20150923 15
Recent discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas with distinct clinical presentations and pathological features. Here we describe three women with hyperaldosteronism, two who presented in pregnancy and one who presented after menopause. Their aldosterone-producing adenomas harbored activating mutations of CTNNB1, encoding β-catenin in the Wnt cell-differentiation pathway, and expressed LHCGR and GNRHR, encoding gonadal receptors, at lev ...[more]
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