Ontology highlight
ABSTRACT:
SUBMITTER: Fischer M
PROVIDER: S-EPMC4612452 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Fischer Martin M Steiner Lydia L Engeland Kurt K
Cell cycle (Georgetown, Tex.) 20140101 19
The predominant function of the tumor suppressor p53 is transcriptional regulation. It is generally accepted that p53-dependent transcriptional activation occurs by binding to a specific recognition site in promoters of target genes. Additionally, several models for p53-dependent transcriptional repression have been postulated. Here, we evaluate these models based on a computational meta-analysis of genome-wide data. Surprisingly, several major models of p53-dependent gene regulation are implaus ...[more]