Dataset Information

The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis.

ABSTRACT: It has been reported that the double von Willebrandfactor domain A (DVWA) gene polymorphisms may be associated with osteoarthritis (OA) risk. However, some studies yielded conflicting results. Therefore, we conducted a comprehensive meta-analysis to identify the association of DVWA gene polymorphisms and the susceptibility to OA. We conducted a systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI) and Wangfang databases up to May 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. Statistical analyses were performed with STATA 11.0 software. In total, 11 studies from five articles with 13,579 subjectswere included in this meta-analysis. The overall results indicated that there was a significant association between DVWA rs7639618 polymorphism and OA susceptibility observed in dominant and co-dominant models. In the subgroup analysis, we found that DVWA gene rs7639618 and rs11718863 polymorphism was associated with OA risk in Asians (GG+GA vs. AA: OR=1.34, P<0.001; G vs. A: OR=1.29, P=0.019). Furthermore, for rs7639618, the dominant (GG+GA) and heterozygote (GA) may strongly increase the knee OA susceptibility (GG+GA vs. AA: OR=1.27, P<0.001), especially in Asians. In addition, as for rs11718863, a trend of increased knee OA risk was found in Asians (TT+TA vs. AA: OR=1.54, P<0.001). In conclusion, the meta-analysis results suggested that DVWArs7639618 and rs11718863 polymorphisms may increase the risk of knee OA susceptibility in Asians, but not in Caucasians. However, no significant association between SNP rs7639618 and rs11718863 and hip OA risk was identified.

SUBMITTER: Wang D

PROVIDER: S-EPMC4612852 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis.

Wang Duan D Zhou Kai K Chen Zhi Z Yang Fei F Zhang Chao C Zhou Zongke Z Pei Fuxing F

International journal of clinical and experimental medicine 20150815 8

It has been reported that the double von Willebrandfactor domain A (DVWA) gene polymorphisms may be associated with osteoarthritis (OA) risk. However, some studies yielded conflicting results. Therefore, we conducted a comprehensive meta-analysis to identify the association of DVWA gene polymorphisms and the susceptibility to OA. We conducted a systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI) and Wangfang databases up to May 15, 2015. Odds ratio (OR) and 95% c ...[more]

PMID: 26550167

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Project description:BackgroundOsteoarthritis of the knee is an irreversible disease that causes great pain, and genetic factors play an important role in its occurrence and development. There have been many studies on the correlation between ADAM12 polymorphisms and genetic susceptibility to osteoarthritis, but the results remain inconclusive.MethodsPapers from PubMed, Web of Science, EMbase, Springer, SCOPUS, Google Scholar and other databases were systematically retrieved with a cut-off of January 2022. All case-control studies on ADAM12 rs3740199, rs1871054, rs1044122, and rs1278279 polymorphisms and osteoarthritis were searched. Fixed or random effects models were used for pooled analysis with OR values and 95% confidence intervals (CI), and publication bias was assessed. In addition, the false-positive reporting probability test was used to assess the confidence of a statistically significant association.ResultsEleven articles were included, which included 3332 patients with osteoarthritis and 5108 healthy controls. Meta-analysis showed that the rs1871054 polymorphism of ADAM12 was associated with osteoarthritis in dominant, recessive, allelic, and homozygote genetic models [C vs. T: OR = 1.34 95% CI (1.05, 1.71), P < 0.001]. Our subgroup analysis revealed an association between the ADAM12 polymorphism rs1871054 in Asians and osteoarthritis [C vs. T: OR = 1.61, 95% CI (1.25, 2.08), P < 0.001], albeit this was only for three studies. In addition, the ADAM12 polymorphism rs1871054 is associated with osteoarthritis in patients younger than 60 years of age [C vs. T: OR = 1.39, 95% CI (1.01, 1.92), P = 0.289]; however, the ADAM12 gene rs3740199, rs1044122, and rs1278279 site polymorphisms were not significantly. Furthermore, when assessing the confidence of the positive results, the positive results were found to be credible (except for Age < 60).ConclusionPolymorphism at the rs1871054 site of ADAM12 is associated with genetic susceptibility to osteoarthritis, but rs3740199, rs1044122, and rs1278279 site polymorphisms are not.

Dataset Information

The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis.

Publications

The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis.

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