Leptin receptor gene polymorphisms and risk of hypertension: a meta-analysis.
Ontology highlight
ABSTRACT: Objective
To assess the relationship between the polymorphisms of leptin receptor gene and hypertension.Methods
Meta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein".Results
Fifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene polymorphism was significantly higher in hypertension patients than in control (OR=1.36, 95% CI=1.23-1.51, P<0.00001). However, no statistically significant difference was found in Lys109Arg polymorphism between hypertension patients and control (OR=0.99, 95% CI=0.85-1.16, P=0.91).Conclusion
Gln223Arg, but not Lys109Arg gene polymorphism, is higher in hypertension patients, suggesting that patients with Gln223Arg allele carry a higher risk to develop hypertension.
SUBMITTER: Lian Y
PROVIDER: S-EPMC4613096 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Leptin receptor gene polymorphisms and risk of hypertension: a meta-analysis.
Lian Yingdong Y Tang Zhijun Z Xie Yuxi Y Chen Zongxiang Z
International journal of clinical and experimental medicine 20150815 8
<h4>Objective</h4>To assess the relationship between the polymorphisms of leptin receptor gene and hypertension.<h4>Methods</h4>Meta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein".<h4>Results</h4>Fifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene p ...[more]
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