Ontology highlight
ABSTRACT:
SUBMITTER: Machida T
PROVIDER: S-EPMC4613253 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Machida Tatsuya T Tomofuji Takaaki T Ekuni Daisuke D Maruyama Takayuki T Yoneda Toshiki T Kawabata Yuya Y Mizuno Hirofumi H Miyai Hisataka H Kunitomo Muneyoshi M Morita Manabu M
International journal of molecular sciences 20150907 9
The aim of this study was to examine whether salivary exosomal miRNAs could be identified as aging biomarkers. Fifteen young healthy volunteers (median age, 21.0 years) and 13 old individuals (median age, 66.0 years) were recruited. Unstimulated whole saliva was collected, salivary exosomes were isolated, and total RNA was extracted. In a microarray, 242 miRNAs were commonly detected in these two mixed samples. Based on the cut-off values of 2- or 0.5-fold changes (FC) and regulatory power for a ...[more]