Ontology highlight
ABSTRACT:
SUBMITTER: Masuda K
PROVIDER: S-EPMC4613358 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Masuda Kosuke K Toda Tomohisa T Shinmyo Yohei Y Ebisu Haruka H Hoshiba Yoshio Y Wakimoto Mayu M Ichikawa Yoshie Y Kawasaki Hiroshi H
Scientific reports 20151020
One of the most prominent features of the cerebral cortex of higher mammals is the presence of gyri. Because malformations of the cortical gyri are associated with severe disability in brain function, the mechanisms underlying malformations of the cortical gyri have been of great interest. Combining gyrencephalic carnivore ferrets and genetic manipulations using in utero electroporation, here we successfully recapitulated the cortical phenotypes of thanatophoric dysplasia (TD) by expressing fibr ...[more]