Ontology highlight
ABSTRACT:
SUBMITTER: Cutts EE
PROVIDER: S-EPMC4613516 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Cutts Erin E EE Inglis Alison A Stansfeld Phillip J PJ Vakonakis Ioannis I Hatzopoulos Georgios N GN
Biochemical Society transactions 20151001 5
Centrioles are evolutionarily conserved cylindrical cell organelles with characteristic radial symmetry. Despite their considerable size (400 nm × 200 nm, in humans), genetic studies suggest that relatively few protein components are involved in their assembly. We recently characterized the molecular architecture of the centrosomal P4.1-associated protein (CPAP), which is crucial for controlling the centriolar cylinder length. Here, we review the remarkable architecture of the C-terminal domain ...[more]