Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama Y
PROVIDER: S-EPMC4613835 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yokoyama Yuhki Y Zhu Hengrui H Zhang Rugang R Noma Ken-ichi K
Cell cycle (Georgetown, Tex.) 20150101 13
Although cellular senescence is accompanied by global alterations in genome architecture, how the genome is restructured during the senescent processes is not well understood. Here, we show that the hCAP-H2 subunit of the condensin II complex exists as either a full-length protein or an N-terminus truncated variant (ΔN). While the full-length hCAP-H2 associates with mitotic chromosomes, the ΔN variant exists as an insoluble nuclear structure. When overexpressed, both hCAP-H2 isoforms assemble th ...[more]