Ontology highlight
ABSTRACT:
SUBMITTER: Cambria E
PROVIDER: S-EPMC4613866 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Cambria Elena E Renggli Kasper K Ahrens Caroline C CC Cook Christi D CD Kroll Carsten C Krueger Andrew T AT Imperiali Barbara B Griffith Linda G LG
Biomacromolecules 20150710 8
Synthetic extracellular matrices are widely used in regenerative medicine and as tools in building in vitro physiological culture models. Synthetic hydrogels display advantageous physical properties, but are challenging to modify with large peptides or proteins. Here, a facile, mild enzymatic postgrafting approach is presented. Sortase-mediated ligation was used to conjugate human epidermal growth factor fused to a GGG ligation motif (GGG-EGF) to poly(ethylene glycol) (PEG) hydrogels containing ...[more]