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Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.

ABSTRACT: Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8 transcriptionally suppresses CDK1, thus triggering the polyploidization of decidual cells. E2F8-mediated polyploidization is a response to stresses which are accompanied by decidualization. Interestingly, polyploidization is not detected during human decidualization with the down-regulation of E2F8, indicating differential expression of E2F8 may lead to the difference of decidual cell polyploidization between mice and humans.

SUBMITTER: Qi QR

PROVIDER: S-EPMC4614110 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.

Qi Qian-Rong QR Zhao Xu-Yu XY Zuo Ru-Juan RJ Wang Tong-Song TS Gu Xiao-Wei XW Liu Ji-Long JL Yang Zeng-Ming ZM

Cell cycle (Georgetown, Tex.) 20150101 12

Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8 transcriptionally suppresses CDK1, thus triggering the polyploid ...[more]

PMID: 25892397

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Dataset Information

Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.

Publications

Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.

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