Ontology highlight
ABSTRACT:
SUBMITTER: Chikashige Y
PROVIDER: S-EPMC4614384 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chikashige Yuji Y Arakawa Shin'ichi S Leibnitz Kenji K Tsutsumi Chihiro C Mori Chie C Osakada Hiroko H Murata Masayuki M Haraguchi Tokuko T Hiraoka Yasushi Y
Scientific reports 20151021
In ribosome biogenesis, a large fraction of ribosomes is used for producing ribosomal proteins themselves. Here, we applied simulation and experimentation to determine what fraction of ribosomes should be allocated for the synthesis of ribosomal proteins to optimize cellular economy for growth. We define the "r-fraction" as the fraction of mRNA of the ribosomal protein genes out of the total mRNA, and we simulated the effect of the r-fraction on the number of ribosomes. We then empirically measu ...[more]