Ontology highlight
ABSTRACT:
SUBMITTER: Askmyr M
PROVIDER: S-EPMC4614391 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Askmyr Maria M White Kirby E KE Jovic Tanja T King Hannah A HA Quach Julie M JM Maluenda Ana C AC Baker Emma K EK Smeets Monique F MF Walkley Carl R CR Purton Louise E LE
Scientific reports 20151021
The gp130 receptor and its binding partners play a central role in cytokine signalling. Ciliary neurotrophic factor (CNTF) is one of the cytokines that signals through the gp130 receptor complex. CNTF has previously been shown to be a negative regulator of trabecular bone remodelling and important for motor neuron development. Since haematopoietic cell maintenance and differentiation is dependent on the bone marrow (BM) microenvironment, where cells of the osteoblastic lineage are important regu ...[more]