Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Jimenez C
PROVIDER: S-EPMC4614917 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Sánchez-Jiménez Carmen C Izquierdo José M JM
Cell cycle (Georgetown, Tex.) 20150101 13
T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins discovered in 1991 as components of cytotoxic T lymphocyte granules. They act in the nucleus as regulators of transcription and pre-mRNA splicing. In the cytoplasm, TIA1 and TIAR regulate and/or modulate the location, stability and/or translation of mRNAs. As knowledge of the different genes regulated by these proteins and the cellular/biological programs in which they are involved increases, it is ev ...[more]