Resistance to targeted cancer drugs through hepatocyte growth factor signaling.
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ABSTRACT:
SUBMITTER: Heynen GJ
PROVIDER: S-EPMC4615055 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Resistance to targeted cancer drugs through hepatocyte growth factor signaling.
Heynen Guus J J E GJ Fonfara Aldona A Bernards René R
Cell cycle (Georgetown, Tex.) 20140101 24
Cancer therapeutics that target a signaling pathway to which the cancer cells are addicted can deliver dramatic initial responses, but resistance is nearly always inevitable. A variety of mechanisms that cancer cells employ to escape from targeted cancer drugs have been described. We review here the role of Hepatocyte Growth Factor (HGF) and its receptor MET in drug resistance. We present data demonstrating that HGF can confer resistance to a number of kinase inhibitors in a variety of cancer ce ...[more]
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