Impaired light detection of the circadian clock in a zebrafish melanoma model.
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ABSTRACT:
SUBMITTER: Hamilton N
PROVIDER: S-EPMC4615116 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Impaired light detection of the circadian clock in a zebrafish melanoma model.
Hamilton Noémie N Diaz-de-Cerio Natalia N Whitmore David D
Cell cycle (Georgetown, Tex.) 20150101 8
The circadian clock controls the timing of the cell cycle in healthy tissues and clock disruption is known to increase tumourigenesis. Melanoma is one of the most rapidly increasing forms of cancer and the precise molecular circadian changes that occur in a melanoma tumor are unknown. Using a melanoma zebrafish model, we have explored the molecular changes that occur to the circadian clock within tumors. We have found disruptions in melanoma clock gene expression due to a major impairment to the ...[more]
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