Ontology highlight
ABSTRACT:
SUBMITTER: Park JH
PROVIDER: S-EPMC4615599 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Nature genetics 20100620 7
We report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies (GWASs). We propose statistical power calculations for future GWASs using estimated distributions of effect sizes. Using reported GWAS findings for height, Crohn's disease and breast, prostate and colorectal (BPC) cancers, we determine that each of these traits is likely to harbor additional loci wi ...[more]