Ontology highlight
ABSTRACT:
SUBMITTER: Pan Y
PROVIDER: S-EPMC4615722 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Pan Yi Y Liang Hongwei H Chen Weixu W Zhang Hongjie H Wang Nan N Wang Feng F Zhang Suyang S Liu Yanqing Y Zhao Chihao C Yan Xin X Zhang Junfeng J Zhang Chen-Yu CY Gu Hongwei H Zen Ke K Chen Xi X
RNA biology 20150101 3
MicroRNA-200b and microRNA-200c (miR-200b/c) are 2 of the most frequently upregulated oncomiRs in colorectal cancer cells. The role of miR-200b/c during colorectal tumorigenesis, however, remains unclear. In the present study, we report that miR-200b/c can promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs (RECK). Firstly, bioinformatics analysis predicted RECK as a conserved target of miR-200b/c. By overexpressing or knockin ...[more]