Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women.

ABSTRACT: The aim of this study was to investigate whether polymorphisms in the tissue inhibitor of metalloproteinase 3 gene (TIMP3) are associated with the risk of preeclampsia (PE) in Han Chinese women.Nine single TIMP3 tag-single nucleotide polymorphisms were selected by Haploview and genotyped using the Sequenom method in 181 preeclamptic and 203 healthy pregnant women from eastern China.The allele frequencies of the tag-single nucleotide polymorphisms were not significantly different between groups (P?>?0.05). However, the genotype distribution of rs135025 was shown to differ between the multigravidity PE subgroup (>3) and controls under additive (P?=?0.018) and recessive models (P?=?0.008), while the genotype distribution of rs80272 differed significantly between the severe PE subgroup and controls under additive (P?=?0.014) and dominant models (P?=?0.041). Moreover, the H2 haplotype (A-C-G-T-A-A-G-C-G) was found to be associated with the risk of PE (P?=?0.035).Genotypes of rs135025 and rs80272 in TIMP3 may therefore influence susceptibility to PE, and pregnant women carrying the H2 haplotype might be more prone to developing PE.

SUBMITTER: Guo C 

PROVIDER: S-EPMC4615926 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature