Ontology highlight
ABSTRACT:
SUBMITTER: Daniele S
PROVIDER: S-EPMC4616042 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Daniele Simona S Giacomelli Chiara C Zappelli Elisa E Granchi Carlotta C Trincavelli Maria Letizia ML Minutolo Filippo F Martini Claudia C
Scientific reports 20151023
Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them intrinsically more sensitive to prospective therapeutic strategies based on the inhibition of the glycolytic pathway. The enzyme lactate dehydrogenase-A (LDH-A), which catalyses the interconversion of p ...[more]