Light exposure before learning improves memory consolidation at night.
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ABSTRACT:
SUBMITTER: Shan LL
PROVIDER: S-EPMC4616152 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Light exposure before learning improves memory consolidation at night.
Shan Li-Li LL Guo Hao H Song Ning-Ning NN Jia Zheng-Ping ZP Hu Xin-Tian XT Huang Jing-Fei JF Ding Yu-Qiang YQ Richter-Levin Gal G Zhou Qi-Xin QX Xu Lin L
Scientific reports 20151023
Light is recently recognized as a modulator able to activate the hippocampus and modulate memory processing, but little is known about the molecular mechanisms. Here, we report that in mice, a short pulse of white light before learning dramatically improves consolidation of contextual fear memory during the night. The light exposure increases hippocampal active p21-activated kinase 1 (PAK1) and CA1 long-term potentiation (LTP). These light effects are abolished in PAK1 knockout and dominant-nega ...[more]
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