Ontology highlight
ABSTRACT:
SUBMITTER: Cole CB
PROVIDER: S-EPMC4617143 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Cole Christopher B CB Nikpay Majid M Lau Paulina P Stewart Alexandre F R AF Davies Robert W RW Wells George A GA Dent Robert R McPherson Ruth R
Journal of lipid research 20140915 11
Recent genome-wide association studies have identified multiple loci robustly associated with plasma lipids, which also contribute to extreme lipid phenotypes. However, these common genetic variants explain <12% of variation in lipid traits. Adiposity is also an important determinant of plasma lipoproteins, particularly plasma TGs and HDL cholesterol (HDLc) concentrations. Thus, interactions between genes and clinical phenotypes may contribute to this unexplained heritability. We have applied a ...[more]