Ontology highlight
ABSTRACT:
SUBMITTER: Valdearcos M
PROVIDER: S-EPMC4617309 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Valdearcos Martin M Robblee Megan M MM Benjamin Daniel I DI Nomura Daniel K DK Xu Allison W AW Koliwad Suneil K SK
Cell reports 20141211 6
Diets rich in saturated fat produce inflammation, gliosis, and neuronal stress in the mediobasal hypothalamus (MBH). Here, we show that microglia mediate this process and its functional impact. Although microglia and astrocytes accumulate in the MBH of mice fed a diet rich in saturated fatty acids (SFAs), only the microglia undergo inflammatory activation, along with a buildup of hypothalamic SFAs. Enteric gavage specifically with SFAs reproduces microglial activation and neuronal stress in the ...[more]