Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC4617529 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
Tian Yanli Y Zhang Xueli X Li Yuyan Y Shoup Timothy M TM Teng Xin X Elmaleh David R DR Moore Anna A Ran Chongzhao C
Chemical communications (Cambridge, England) 20141105 99
In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice. ...[more]
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