Ontology highlight
ABSTRACT:
SUBMITTER: Bridgeman A
PROVIDER: S-EPMC4617605 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150730 6253
Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, including lentivirus and herpesvirus virions, when these are produced in cGAS-expressing cells. Virions transferred cGAMP to newly infected cells and triggered a STING-dependent antiviral program. These eff ...[more]